As a child Estefan liked to write poetry, and though she took classical guitar lessons, she found them tedious. She had no inkling that she would some day become a popular music star, but music played a very important role for her as a teenager.

After her father's return from Vietnam, he was diagnosed as having multiple sclerosis, possibly as a result of having been exposed to the herbicide Agent Orange while serving in the army. Estefan's mother, who had been a teacher in Cuba, worked to support the family during the day and attended school at night. Young Gloria was left to take care of her father and younger sister. She had little social life, and because she felt the weight of such responsibilities she turned to music as a release.

"When my father was ill, music was my escape," Estefan told Washington Post reporter Richard Harrington. "I would lock myself up in my room for hours and just sing. I wouldn't cry—I refused to cry...Music was the only way I had to just let go, so I sang for fun and for emotional catharsis."