Hyposecretion: diabetes mellitus

Lack of insulin from non working beta cells of pancreatic islets

Type 1: people younger than 20. This is the consequence of autoimmune destruction of islet beta cells.

Type 2: people over 40 and overweight. Diet and exercise can reverse symptoms.

Symptoms:

1. Hyperglycemia

2. Ketoacidosis- lead to diabetic coma and fatal