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- Gastrointestinal perforation, some cases fatal, has occurred in up to 3.2% of bevacizumab-treated patients. Discontinue bevacizumab if gastrointestinal perforation or wound dehiscence occurs.
- Discontinue at least 28 days prior to elective surgery.
- Do not initiate bevacizumab for at least 28 days after surgery and until the surgical wound is fully healed.
Black box warring of bevacizumab