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氯吡格雷vs.替格瑞洛
ONSET/OFFSET研究：
（1）180 mg负荷剂量替格瑞洛较600 mg负荷剂量氯吡格雷起效更快（30分钟内）；
（2）抑制血小板聚集作用（IPA）显著较高（41%vs.8%）；
（3）无论负荷剂量后24 h内，还是6周维持阶段，替格瑞洛抑制血小板聚集的作用均优于氯吡格雷。
PLATO研究遗传学亚组：
无论CYP2C19基因型为何，替格瑞洛均较氯吡格雷显著降低主要复合终点（心血管死亡、心梗、卒中）发生率达23%。
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