What Are the Symptoms of Krabbe Disease?

Generally, the younger the age of onset of Krabbe disease, the faster the disease will progress. People who develop Krabbe disease later in life may have less severe symptoms than infants who get the disease.

Early-Onset Krabbe Disease

Symptoms of early-onset Krabbe disease include

feeding problems

fevers

vomiting

loss of head control

irritability and excessive crying

poor coordination of movement or stiffness

severe seizures

spasms or jerking of the arms and legs

changes in muscle tone

deterioration of mental and motor function

deafness and blindness

Late-Onset Krabbe Disease

Symptoms of late-onset Krabbe disease in older children and adolescents include

progressive loss of vision leading to blindness

difficulty walking

muscle weakness or rigid muscles