Down Syndrome is as common in males as it is in females. But there are odds of having Down Syndrome by age.

At age 25, the likelihood is 1 in 1,300
At age 30, the likelihood is 1 in 900
At age 35, the likelihood is 1 in 350
At age 42, the likelihood is 1 in 55
At age 49, the likelihood is 1 in 25