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Hiponatremia por exceso de soluto
Como con la hiperglucemia sin tratamiento o al administrar manitol. La glucosa ejerce una fuerza osmótica en el espacio extracelular y origina un desplazamiento del agua desde el espacio intracelular hasta el extracelular. Por lo tanto, es posible observar hiponatriemia cuando la presión osmótica efectiva del espacio extracelular es normal o incluso alta.
Finalmente, los aumentos extremos de lípidos y proteínas en plasma pueden causar seudohiponatriemia, ya que no existe una disminución verdadera del sodio extracelular en relación con el agua.
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