Seth Macfarlane has made many claims on the argument that theists place faith in an imaginary being. He usually then makes the case that science shows proof or evidence of any scientific discovery. Then he reverts back to conclusion that people should logically think about the situation at hand and reasonably solve it.

Theists would argue the uncertainties of science. Many science findings are at first a hypothesis which are then tested many times to see the accuracy of that finding. However there are theories that are not able to be tested that seem very logical, such as the case of Dark matter and the Multiverse. It seems illogical for people to look into a theory that cannot be tested at this time but there are still believers. Yet for some reason when referring to "God" since we cannot solve Him then that must mean He is not real,