The earliest known growth of Opium is in Mesopotamia, in 3400 B.C.

In 1806, a German chemist named Friedrich Wilhelm extracted Morphine from opium

The Opium Exclusion Act in 1909 banned sale of Opium intended to be smoked, which made Opium the first drug to be made illegal.

Hydrocodone & Oxycodone are synthetic,

producing opium-like effect

History of Opioids

The Opium Poppy