Definition: a nonsense mutation is a mutation where a sense codon that corresponds to one of the 21 amino acids specified by the genetic code is altered to a chain-terminating codon.

Example: Hurler syndrome, which is a genetic disorder that results in the build up of glycosaminoglycans because of the deficiency of alpha L iduronidase, an enzyme responsible for the degradation of mucopolysaccharides in lysosomes.

Nonsense