Physiologic Anatomy of Biliary Secretion

1. Initial portion is secreted by the principal functional cells of the liver, the
this initial secretion contains large amounts of , , and


2. Bile flows in the canaliculi toward the interlobular septa, where the canaliculi empty
into terminal bile ducts and then into progressively larger ducts, finally reaching the
hepatic duct and common bile duct

Hepatocytes;

bile acids

cholesterol

other organic

constituents

- is secreted continually by the liver cells, but normally stored in the gallbladder until
needed in the duodenum
- maximum volume that the gallbladder can hold is only 30 to 60 milliliters
- 12 hours of bile secretion (usually about 450 milliliters) can be stored in the bladder

Gallbladder absorption - caused by active transport of sodium through the gallbladder
epithelium
- followed by secondary absorp- tion of chloride ions, water, and
most other diffusible

Storing and Concentrating Bile in the GallbladderBile