Liver Secretion of Cholesterol and Gallstone Formation

If biliary cholesterol output could be increased with no risk of increase in gallstone formation or decreased without altering overall cholesterol homeostasis, drugs might open new therapeutic horizons for atherosclerosis and gallstone

The amount of cholesterol in the bile is determined partly by the quantity of fat that the person eats, because liver cells synthesize cholesterol as one of the products of fat metabolism in the body.
For this reason, people on a high-fat diet over a period of years are prone to the development of gallstones.