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Fluid Mosaic Model
--Plasma membrane is a double layer (bilayer) of lipids with imbedded, dispersed proteins
--A bilayer consists of phospholipids, cholesterol, and glycolipids
--Proteins are trapped in the bilayer: Extra/intracellular regions are hydrophilic
--Transdomain regions are hydrophobic
The Lipids of the Bilayer
Phospholipids have hydrophobic and hydrophilic bipoles
Glycolipids are lipids with bound carbohydrate
Cholesterol
--The bilayer is self-orienting (forms by itself)
-self assembly into spheres
-seals quickly if torn
--The majority of the membrane lipids are unsaturated which “kinks” the tails
Functions of Membrane Proteins
---Transport
--- Enzymatic activity
---Receptors for signal transduction
Intercellular adhesion
---Cell-cell recognition
--- Attachment to cytoskeleton and extracellular matrix
22. Describe the chemical. Composition of the plasma membrane and relate it to membrane functions.
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